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?Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. Perturbations of DA signaling are implicated in the pathogenesis or exploited in the treatment of many neuropsychiatric diseases, including Parkinson's disease (PD), addiction, schizophrenia, obsessive compulsive disorder, and Tourette's syndrome. Although the precise mechanisms employed by DA to exert its control over behavior are not fully understood, DA is known to regulate many electrical and biochemical aspects of neuronal function including excitability, synaptic transmission, integration Womens Nike Free Run and plasticity, protein trafficking, and gene transcription. In this Review, we discuss the actions of DA on ionic and synaptic signaling in neurons of the prefrontal cortex and striatum, brain areas in which Cheap Nike Free Run dopaminergic dysfunction is thought to be central to disease.Copyright 2012 Elsevier Inc. All rights reserved.Comment inDopamine neurons are multi-neurotransmitter neurons. [Mov Disord. 2013]Dopamine neurons are multi-neurotransmitter neurons.Benoit-Marand M. Mov Disord. 2013 Aug; 28(9):1211. Epub 2013 Aug 7.

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